Glutamate-related biomarkers in drug development for disorders of the nervous system
workshop summary
Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. This book investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Beyond its central premise, the book can be read through the connected lenses of Mental Health, Nonfiction. Those themes offer useful points of attention as the characters, ideas, or world develop, especially where the book complicates the expectations of its primary category.
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What the reading experience may hold
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Mental Health · Nonfiction
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Catalog signals suggest abuse or trauma, mental-health concerns. These notes may not be complete; consult a publisher or reader-supplied guide when detailed warnings matter.
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Balanced tone · Steady pace
Works well for a focused weekend or a few concentrated sittings.
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Readers who want a thoughtful experience and enjoy noticing the connections beneath a book’s surface story.
This book's DNA
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A quick reading snapshot
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- ISBN-13
- 978-0-3092-1221-2
- Language
- English
- Edition record
- OL25095125M
A more thoughtful way into this book
This guide uses the edition details and category signals above to help you choose deliberately. It does not replace the author's work or a full review.
Works well for a focused weekend or a few concentrated sittings.
Begin with its place in Mental Health, then notice where the book resists that label.
Read for connection, not completion.
Mark one passage that sharpens the book's central concern and one that complicates it. That tension often reveals more than a quick summary.
Three questions to carry with you
- Which ideas feel usable in your actual circumstances—not only persuasive on the page?
- Where does the author distinguish evidence, experience, and opinion?
- What would a small, humane experiment with one idea look like?
Editorial framework by Wesley Bryan, BookenDeX Founder and Editor.
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