Applied Statistical Genetics with R
for population-based association studies
"The vast array of molecular level information now available presents exciting opportunities to characterize the genetic underpinnings of complex diseases while discovering novel biological pathways to disease progression. In this introductory graduate level text, Dr. Foulkes elucidates core concepts that undergird the wide range of analytic techniques and software tools for the analysis of data derived from population-based genetic investigations. Applied Statistical Genetics with R offers a clear and cogent presentation of several fundamental statistical approaches that researchers from multiple disciplines, including medicine, public health, epidemiology, statistics and computer science, will find useful in exploring this emerging field. Couched in the language of biostatistics, this text can be easily adopted for public health and medical school curricula. The text covers key genetic data concepts and statistical principles to provide the reader with a strong foundation in methods for candidate gene and genome-wide association studies. These include methods for unobservable haplotypic phase, multiple testing adjustments, and high-dimensional data analysis. Emphasis is on analysis of data arising from studies of unrelated individuals and the potential interplay among genetic factors and more traditional, epidemiological risk factors for disease. While theoretically rigorous, the analytic techniques are presented at a level that will appeal to researchers and students with limited knowledge of statistical genetics. The text assumes the reader has completed a first course in biostatistics, uses publicly available data sets for illustration, and provides extensive examples using the open source, publicly available statistical software environment R."--Publisher's website.
Beyond its central premise, the book can be read through the connected lenses of Nonfiction. Those themes offer useful points of attention as the characters, ideas, or world develop, especially where the book complicates the expectations of its primary category.
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What the reading experience may hold
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Nonfiction
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Dark tone · Steady pace
A comfortable full-length choice for steady daily reading.
A good fit if…
Readers who want a thoughtful experience and enjoy noticing the connections beneath a book’s surface story.
This book's DNA
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A quick reading snapshot
Edition facts and catalog signals to help you decide whether this book fits what you want to read next.
- ISBN-13
- 978-0-3878-9606-9
- Language
- English
- Edition record
- OL30463228M
A more thoughtful way into this book
This guide uses the edition details and category signals above to help you choose deliberately. It does not replace the author's work or a full review.
A comfortable full-length choice for steady daily reading.
Begin with its place in Nonfiction, then notice where the book resists that label.
Read for connection, not completion.
Mark one passage that sharpens the book's central concern and one that complicates it. That tension often reveals more than a quick summary.
Three questions to carry with you
- Whose perspective organizes the story, and whose perspective remains outside it?
- Which sources or lived experiences carry the author’s central argument?
- How does the book change the way you understand its larger subject?
Editorial framework by Wesley Bryan, BookenDeX Founder and Editor.
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